Noninvasive fetal genotyping of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders
Abstract Background High-cost, time-consuming and complex processes of several current approaches limit the use of noninvasive prenatal diagnosis (NIPD) for monogenic disorders in clinical application.Thus, a more cost-effective and easily implementable approach is required.Methods We established a low-cost and convenient test to noninvasively dedu